![]() The similarity of MDA and MDMA pharmacokinetics suggests that the greater duration of MDA effects is due to pharmacodynamics rather than pharmacokinetics. There was considerable between-subject variation in MDA/HMA ratios. Cmax and AUC 0-∞ for MDA were 229 ± 39 (mean ± SD) and 3636 ± 958 µg/L for MDA and 92 ± ± 741 µg/L for the metabolite 4-hydroxy-3-methoxyamphetamine (HMA). MDA self-report effects lasted longer than those of MDMA, with MDA effects remaining elevated at 8 h while MDMA effects resolved by 6 h. ![]() MDA self-report effects shared features with MDMA as well as with classical psychedelics. ![]() MDA induced robust increases in heart rate and blood pressure and increased cortisol and prolactin to a similar degree as MDMA. We conducted a within-subjects, double-blind, placebo-controlled study of 1.4 mg/kg oral racemic MDA and compared results to those from our prior similar studies with 1.5 mg/kg oral racemic MDMA. Yet the first known drug with such properties, 3,4-Methylenedioxyamphetamine (MDA), remains poorly studied and its pharmacokinetics in humans are unknown. Understanding their mechanisms can benefit from clinical experiments with related drugs. Common (small or sensitive people) 60 - 90 mg. Entactogens such as 3,4-Methylenedioxymethamphetamine (MDMA, “molly”, “ecstasy”) appear to have unusual, potentially therapeutic, emotional effects. MDA is a psychotropic compound in its own right, administered both orally and intravenously in doses of 50 - 250 mg as an illict drug. Erowids current view is that the required dose of MDA vs MDMA are very similar, but result in slightly different effects (MDA is more physically stimulating while MDMA is more empathogenic at the same dose).
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